Texas YK-11 | Advanced Research Compound
Unleash the frontier of muscle biology research with Texas YK-11, a premium-grade synthetic steroidal compound engineered for advanced in vitro and preclinical evaluation. Combining the cellular characteristics of a Selective Androgen Receptor Modulator (SARM) with the unique properties of a myostatin inhibitor, YK-11 remains one of the most intriguing and heavily investigated compounds in modern molecular pharmacology.
Mechanism of Action: The Dual-Action Path
Unlike standard research compounds that solely bind to androgen receptors, Texas YK-11 operates through a distinct, dual-pathway mechanism that sets it apart in laboratory models:
Androgen Receptor Partial Agonism: YK-11 selectively attaches to androgen receptors in musculoskeletal tissue. It accelerates the nuclear translocation of these receptors, promoting the transcription of key structural proteins without triggering full, classic systemic androgenic pathways.
Follistatin Upregulation & Myostatin Inhibition: The most prominent feature of YK-11 is its ability to induce the expression of Follistatin (Fst). Follistatin is a naturally occurring glycoprotein that binds to and blocks Myostatin—a regulatory protein responsible for putting the brakes on muscle tissue growth. By downregulating myostatin activity, YK-11 effectively allows cellular models to bypass traditional genetic limitations on muscle mass accretion.
Core Areas of Research Exploration
In preclinical, cell-culture, and animal models, investigators utilize YK-11 to observe several key physiological markers:
1. Accelerating Myogenic Differentiation
Studies on C2C12 myoblasts show that YK-11 significantly boosts the expression of crucial myogenic regulatory factors, including MyoD, Myf5, and myogenin. This drives cellular adaptation and rapid muscle fiber differentiation far more potently than standard endogenous hormones like DHT.
2. Enhanced Bone Mineralization & Density
Research indicates that YK-11 upregulates osteoblastic proliferation. By increasing the expression of osteoblast differentiation markers like osteoprotegerin and osteocalcin, it is actively studied for its potential applications in combating bone density loss and structural frailty.
3. Protection Against Muscle Wasting
Because it acts as a direct countermeasure to muscle-degrading proteins, YK-11 is a primary subject in studies looking at severe catabolic conditions, cachexia (muscle wasting), and sepsis-induced lean tissue degeneration.
Technical Specifications
| Parameter | Specification |
| Chemical Name | (20E)-17α,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid, methyl ester |
| CAS Number | 1370003-76-1 |
| Molecular Formula | $C_{25}H_{34}O_{6}$ |
| Molar Mass | $430.54 \text{ g/mol}$ |
| Purity Profile | ≥98% via HPLC analysis |
| Form | High-stability research solution / powder matrix |
⚠️ LABORATORY RESEARCH NOTICE
This product is a highly potent chemical synthesized strictly for laboratory research, in vitro validation, and preclinical animal studies. It is not approved for human consumption, veterinary use, or therapeutic administration. Handling should be restricted to qualified professionals using appropriate personal protective equipment (PPE) in compliance with institutional safety protocols.
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